1k3t

Publication Abstract from PubMed
The structure of the glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) from Trypanosoma cruzi complexed with chalepin, a natural product from Pilocarpus spicatus, has been determined by X-ray crystallography to 1.95 A resolution. The structure is in the apo form without cofactors in the subunits of the tetrameric gGAPDH in the asymmetric unit. Unequivocal density corresponding to the inhibitor was clearly identified in one monomer. The final refined model of the complex shows extensive conformational changes when compared with the native structure. The mode of binding of chalepin to gGAPDH and its implications for inhibitor design are discussed.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure
1K3T is a 4 chains structure of sequences from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference
Page seeded by OCA on Mon Feb 16 14:04:28 2009